|
|
|
|
Factors significantly related to the development of an intracerebral hematoma were TPA dose and diastolic hypertension.Intracerebral hematomas developed in 4(18%)of 22 patients given a TPA dose of at least 0.90 mg/kg versus only 1 hematoma in the remaining 72 patients(1%;P<.02,Fisher's exact test).Four(18%)of 22 patients who had initial diastolic blood pressures of at least 100 mm Hg suffered an intracerebral hematoma versus only 1(1%)of 72 patients((P<.02)with lower initial diastolic pressures. Since the study was not designed to test specific safety hypotheses, results must not be overinterpreted.Nonetheless,these data emphasize the need for caution in both patient and dose selection for further studies of thrombolytic agents in stroke. |
|